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货号： bs-11104R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11104R-PE-Cy3
- 英文名称
- Anti-Neurexin II alpha/PE-Cy3
- 中文名称
- PE-Cy3标记的轴突蛋白2抗体
- 别 名
- Neurexin 2; Neurexin-2; Neurexin2; Neurexin II; Neurexin II alpha; NRXN 2; NRXN-2; NRXN2; NRX2A_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 细胞粘附分子 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 182kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Neurexin 2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Function:
Neurexin 2 alpha belongs to the Neurexin family, a group of neuronal proteins that function as cell adhesion molecules during synaptogenesis and intracellular signaling. Mammalian genomes contain just three neurexin genes. However, many neurexin isoforms may be expressed through the use of two alternative promoters and alternative splicing at up to five different positions.
Subunit:
The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL.
Subcellular Location:
Membrane; single-pass type I membrane protein.
Tissue Specificity:
Predominantly expressed in brain.
Similarity:
Belongs to the neurexin family.
Contains 3 EGF-like domains.
Contains 6 laminin G-like domains.
Database links:Entrez Gene: 9379 Human
Entrez Gene: 18190 Mouse
Entrez Gene: 116595 Rat
SwissProt: Q9P2S2 Human
SwissProt: Q63374 Rat
Unigene: 372938 Human
Unigene: 329616 Mouse
Unigene: 414022 Mouse
Unigene: 11282 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.