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货号： bs-23768R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23768R-PE
- 英文名称
- Anti-LFABP/FABP-1/PE
- 中文名称
- PE标记的肝脏型脂肪酸结合蛋白抗体
- 别 名
- FABP 1; FABP1; FABPL; Fatty Acid Binding Protein 1; Fatty acid binding protein 1 liver; Fatty Acid Binding Protein; Fatty acid-binding protein liver; L FABP; L-FABP; FABPL_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 14kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LFABP/FABP-1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Fatty acid binding proteins (FABP) are small (approximately 13-14 kDa) intracellular proteins with a high degree of tissue specificity. FABPs are a class of cytoplasmic proteins that bind long chain fatty acids. They are abundantly present in various cell types and seem to play an important role in the intracellulair utilization of fatty acids. There are at least six distinct types of FABP, each showing a specific pattern of tissue expression. FABP leaks, due to its small size, rapidly out of ischemically damaged dying cells leading to a rise in serum levels. Liver FABP is a sensitive marker for cell damage of liver cells in vitro and in vivo. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. Next to this L FABP is a marker for rapid hepatocyte lysis in vitro (as for example in toxicology assays) and for detection of liver damage during and after transplantation.
Function:
Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Database links:
Entrez Gene: 2168HumanEntrez Gene: 14080Mouse
Entrez Gene: 24360Rat
Omim: 134650Human
SwissProt: P07148Human
SwissProt: P12710Mouse
SwissProt: P02692Rat
Unigene: 380135Human
Unigene: 22126Mouse
Unigene: 36412Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肝脏型脂肪酸结合蛋白家族是脂质结合蛋白超家族成员，是一族多源性的小分子多肽蛋白,存在于脊椎动物和非脊椎动物的细胞内,在细胞内长链脂肪酸的摄取、转运及代谢调节中发挥着重要作用。LFABP广泛存在于哺乳动物的小肠、肝、心、脑、骨骼肌等多种细胞内，其主要作用是调节脂肪酸的摄取和胞内运输，可将脂肪酸从细胞膜上运送到脂肪酸氧化和甘油三酯及磷脂合成的场所。