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货号： bs-6757R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6757R-HRP
- 英文名称
- Anti-BCA2/ZNF364/HRP
- 中文名称
- 辣根过氧化物酶标记的乳腺癌相关基因2抗体（锌指蛋白364）
- 别 名
- BCA2; Breast cancer associated gene 2; CL469780; Rabring 7; RING finger protein 115; RNF115; Zinc finger protein 364; ZNF364; ZNF 364; RN115_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 细胞类型标志物 肿瘤细胞生物标志物 锌指蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZNF364/BCA2/RNF115
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth.
Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking.
Subunit:
Interacts with RAB7A.
Subcellular Location:
Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity).
Tissue Specificity:
Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.
Post-translational modifications:
RING-type zinc finger-dependent and E2-dependent autoubiquitination.
Similarity:
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 101060478Human
Entrez Gene: 27246Human
Entrez Gene: 67845Mouse
Entrez Gene: 362002Rat
SwissProt: Q9Y4L5Human
SwissProt: Q9D0C1Mouse
Unigene: 523550Human
Unigene: 386792Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.