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货号： bs-7195R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7195R-PE
- 英文名称
- Anti-ZNF238/PE
- 中文名称
- PE标记的锌指蛋白238抗体
- 别 名
- 58 kDa repressor protein; C2H2 171; C2H2171; RP58; TAZ 1; TAZ-1; TAZ1; Transcriptional repressor RP58; Translin associated zinc finger protein 1; Translin-associated zinc finger protein 1; ZBTB18; Zinc finger and BTB domain containing protein 18; Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238; Zinc finger protein C2H2 171; Zinc finger protein C2H2-171; ZN238_HUMAN; ZNF238.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 结合蛋白 锌指蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 58kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZNF238
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Function:
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons (By similarity). Specifically binds the consensus DNA sequence 5-[AC]ACATCTG[GT][AC]-3 which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.
Subcellular Location:
Nucleus. Associates with condensed chromatin.
Tissue Specificity:
Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.
Database links:Entrez Gene: 10472Human
Entrez Gene: 30928Mouse
Entrez Gene: 64619Rat
Omim: 608433Human
SwissProt: Q99592Human
SwissProt: Q9WUK6Mouse
SwissProt: Q9JKY3Rat
Unigene: 69997Human
Unigene: 207206Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.