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货号： bs-2965R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2965R-HRP
- 英文名称
- Anti-Myosin 18B/HRP
- 中文名称
- 辣根过氧化物酶标记的肌球蛋白XVIIIb抗体
- 别 名
- MYO18B; myosin 18B; Unconventional myosin-XVIIIb; BK125H2.1; DKFZp434C2422; DKFZp779C1668; MY18B_HUMAN; MYO18B; myosin XVIIIB.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 282kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Myosin-XVIIIb (1805-1855aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin.Mutations in this gene are associated with lung cancer.
Function:
May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Subunit:
Homodimer. May interact with F actin through the GPA motif (Gly/Pro/Ala-rich).
Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
Tissue Specificity:
Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.
Similarity:
Contains 1 IQ domain.
Contains 1 myosin head-like domain.
Database links:Entrez Gene: 84700 Human
Omim: 607295 Human
SwissProt: Q8IUG5 Human
Unigene: 417959 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.