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货号： bs-7513R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7513R-HRP
- 英文名称
- Anti-BAI1/HRP
- 中文名称
- 辣根过氧化物酶标记的脑特异性血管生成抑制蛋白1抗体
- 别 名
- BAI 1; BAI-1; Brain specific angiogenesis inhibitor 1; mKIAA4089; KIAA4089; R75078; B830018M07Rik; BAI1_HUMAN
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 免疫学 血管内皮细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Sheep,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 170kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BAI1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.
Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
Subunit:
Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to promote the engulfment. Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at cell-cell adhesion sites.
Tissue Specificity:
Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes.
Post-translational modifications:
The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 5 TSP type-1 domains.
Database links:Entrez Gene: 524070 Cow
Entrez Gene: 575 Human
Entrez Gene: 107831 Mouse
Entrez Gene: 362931 Rat
Omim: 602682 Human
SwissProt: O14514 Human
SwissProt: Q3UHD1 Mouse
Unigene: 194654 Human
Unigene: 43133 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.