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货号： bs-7113R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7113R-HRP
- 英文名称
- Anti-FEM 1B/HRP
- 中文名称
- 辣根过氧化物酶标记的FEM1B抗体
- 别 名
- F1A-alpha; F1AA; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; Fem1 homolog b; FEM1 like death receptor binding protein; FEM1-beta; FEM1B; FEM1B_HUMAN; Protein fem-1 homolog B.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 70kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FEM 1B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
Function:
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Subunit:
Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1.
Subcellular Location:
Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
Tissue Specificity:
Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
Similarity:
Belongs to the fem-1 family.
Contains 8 ANK repeats.
Contains 1 TPR repeat.
Database links:Entrez Gene: 10116 Human
Entrez Gene: 14155 Mouse
Entrez Gene: 315745 Rat
Omim: 613539 Human
SwissProt: Q9UK73 Human
SwissProt: Q9Z2G0 Mouse
SwissProt: P0C6P7 Rat
Unigene: 362733 Human
Unigene: 24069 Mouse
Unigene: 219320 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.