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货号： bs-7898R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7898R-HRP
- 英文名称
- Anti-PICK1/HRP
- 中文名称
- 辣根过氧化物酶标记的蛋白激酶Cα相互作用蛋白1抗体
- 别 名
- PICK 1; Pick1; PICK1_HUMAN; PRKCA binding protein; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; Protein interacting with PRKCA; Protein interacting with PRKCA 1; Protein kinase C alpha binding protein; Protein kinase C-alpha-binding protein; Protein that interacts with C kinase 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 46kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PICK1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
Function:
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
Subunit:
Monomer and homodimer.
Subcellular Location:
Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
Similarity:
Contains 1 AH domain.
Contains 1 PDZ (DHR) domain.
Database links:UniProtKB/Swiss-Prot: Q9NRD5.2
Entrez Gene: 9463 Human
Entrez Gene: 18693 Mouse
Entrez Gene: 84591 Rat
Omim: 605926 Human
SwissProt: Q9NRD5 Human
SwissProt: Q62083 Mouse
SwissProt: Q9EP80 Rat
Unigene: 180871 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PICK1是衔接PKCα和膜上众多受体的关键蛋白之一，是细胞质中的膜结合蛋白,在蛋白质转运,以及细胞内信号转导过程中发挥重要作用；而在男性不育方面，PICK1蛋白也是促进精子顶体发育的关键蛋白，缺失PICK1蛋白将导致精子受破坏，失去活动能力和受精能力。