MagCellect Rat CD4+ T Cell Isolation Kit (1 KT)
货号：
MAGR302B 基本售价：
5938.8 元 规格：
1 Kit
产品信息
概述| 货号 | MAGR302B |
| 别名 | CD4 antigen (p55); CD4 antigen; CD4 molecule; CD4 receptor; CD4; CD4mut; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4 |
| 反应种属 | Rat |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 920 (Human); 12504 (Mouse); 24932 (Rat); 403931 (Canine); 493775 (Feline) |
| 应用文献 |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. The role of a nuclear protein, histone H1, on signalling pathways for the maturation of dendritic cells.
Authors: Hsu LW, Chen CL, Nakano T, Lai CY, Chiang KC, Lin YC, Kao YH, Chen SH, Goto T, Sung WC, Yang CH, Cheng YF, Jawan B, Chiu KW, Goto S
Clin. Exp. Immunol., 2008;152(3):576-84.
Species: Rat
Sample Type: Whole Cells
|
| 背景 | CD4 is a transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost, giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells, also known as T helper cells, further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th9, Th17,Th22, Tfh, and Treg cells which regulate humoral and cellular immunity. In human, CD4 is additionally expressed on macrophages, neutrophils, monocytes, NK cells, and neurons and glial cells in the brain. CD4 binds directly to MHC class II molecules on antigen presenting cells. This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a coreceptor for the gp120 surface glycoprotein of HIV-1. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Conventional/Classical Dendritic Cells
- gamma delta T Cells
- Human CD Marker Products
- ICC / IHC Images: CD4
- Infectious Diseases
- Leukocyte Receptors/Markers in Allergy and Asthma
- Leukocyte Receptors/Markers in Tfh Cell Differentiation and Function
- LTi Cells
- Lymphoid Lineage Markers
- Natural Killer T (NKT) Cells
- Regulatory T Cells (Tregs)
- Th1 Cells
- Th17 Cells
- Th2 Cells
- Th22 Cells
- Th9 Cells
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