| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J
PLoS ONE, 2014;9(4):e95332.
Species: Mouse
Sample Type: Whole Cells
TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.
Authors: Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H
J Immunol, 2013;191(11):5420-9.
Species: Mouse
Sample Type: whole cells
Modeling and experimental methods to probe the link between global transcription and spatial organization of chromosomes.
Authors: Iyer K, Maharana S, Gupta S, Libchaber A, Tlusty T, Shivashankar G
PLoS ONE, 2012;7(10):e46628.
Species: Mouse
Sample Type: Whole Cells
Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration.
Authors: Gupta S, Marcel N, Talwar S, Garg M, R I, Perumalsamy L, Sarin A, Shivashankar G
PLoS ONE, 2012;7(9):e43718.
Species: Mouse
Sample Type: Whole Cells
The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
Authors: Jin W, Qi S, Luo H
BMC Immunol., 2011;12(0):68.
Species: Mouse
Sample Type: Whole Cells
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
Authors: Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA
Nat. Immunol., 2009;10(9):981-91.
Species: Mouse
Sample Type: Whole Cells
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Authors: Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA
Nat. Immunol., 2007;8(8):825-34.
Species: Mouse
Sample Type: Whole Cells
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| 背景 | CD4 is a transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost, giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells, also known as T helper cells, further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th9, Th17,Th22, Tfh, and Treg cells which regulate humoral and cellular immunity. In human, CD4 is additionally expressed on macrophages, neutrophils, monocytes, NK cells, and neurons and glial cells in the brain. CD4 binds directly to MHC class II molecules on antigen presenting cells. This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a coreceptor for the gp120 surface glycoprotein of HIV-1. |
