| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth.
Authors: Shiu J, Piazuelo M, Ding H, Czinn S, Drakes M, Banerjee A, Basappa N, Kobayashi K, Fricke W, Blanchard T
Mucosal Immunol, 2015;8(5):1047-59.
Species: Mouse
Sample Type: Whole Cells
Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase.
Authors: Purushothaman D, Marcel N, Garg M, Venkataraman R, Sarin A
J Immunol, 2012;190(1):97-105.
Species: Mouse
Sample Type: whole cells
Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity.
Authors: Nath N, Khan M, Rattan R, Mangalam A, Makkar RS, de Meester C, Bertrand L, Singh I, Chen Y, Viollet B, Giri S
Biochem. Biophys. Res. Commun., 2009;386(1):16-20.
Species: Mouse
Sample Type: Whole Cells
A microbial symbiosis factor prevents intestinal inflammatory disease.
Authors: Mazmanian SK, Round JL, Kasper DL
Nature, 2008;453(7195):620-5.
Species: Mouse
Sample Type: Whole Cells
B cell mediated priming following pneumococcal colonization.
Authors: Rabquer B, Shriner AK, Smithson SL, Westerink MA
Vaccine, 2007;25(0):2036.
Species: Mouse
Sample Type: Whole Cells
Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells.
Authors: Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A
J. Immunol., 2006;177(8):5041-50.
Species: Mouse
Sample Type: Whole Cells
Soluble factors from Leishmania major-specific CD4+T cells and B cells limit L. amazonensis amastigote survival within infected macrophages.
Authors: Mukbel R, Petersen CA, Jones DE
Microbes Infect., 2006;8(9):2547-55.
Species: Mouse
Sample Type: Whole Cells
T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects.
Authors: Beima KM, Miazgowicz MM, Lewis MD, Yan PS, Huang TH, Weinmann AS
J. Biol. Chem., 2006;281(17):11992-2000.
Species: Mouse
Sample Type: Whole Tissue
CD4+ T-cell reconstitution reduces cytomegalovirus in the immunocompromised brain.
Authors: Reuter JD, Wilson JH, Idoko KE, van den Pol AN
J. Virol., 2005;79(15):9527-39.
Species: Mouse
Sample Type: Whole Cells
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| 背景 | CD4 is a transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost, giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells, also known as T helper cells, further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th9, Th17,Th22, Tfh, and Treg cells which regulate humoral and cellular immunity. In human, CD4 is additionally expressed on macrophages, neutrophils, monocytes, NK cells, and neurons and glial cells in the brain. CD4 binds directly to MHC class II molecules on antigen presenting cells. This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a coreceptor for the gp120 surface glycoprotein of HIV-1. |
