Drosophila PhospholipaseCb4 Pure 56 50ug
货号：
612646 基本售价：
16434.0 元 规格：
50ug
产品信息
概述| 货号 | 612646 |
| 描述 | Phospholipase C (PLC) hydrolyzes inositol phospholipids into diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Multiple distinct PLC isoenzymes have been identified and divided into three structural types: α,β , and γ . This classification is based primarily on the location of the conserved X and Y domains, whose structural integrity is essential for a functional catalytic core. The activation of PLC β isoenzymes is uniquely regulated by G protein subunits, while PLC γ is activated following phosphorylation by protein tyrosine kinases. The β subfamily of PLC consists of at least four members: β1,β2,β 3, and β 4. PLC β 4 differs from the other members in that it is not activated by G protein βγ subunits, it is not found in the liver or kidney, and it is inhibited by ribonucleotides. Various isoforms of PL β C4 result from alternative splicing or proteolytic cleavage. PLC β 4 is expressed in retina and brain and knockout mice display ataxia and abnormalities in metabotropic glutamate receptor function in the cerebellum. Thus, PLC β 4 is primarily found in neuronal tissues where it is thought to be important in neurotransmitter signaling pathways. |
| 别名 | PLCβ4 |
| 同种亚型 | IgG1 |
| 反应种属 | Fly (QC Testing) Human, Mouse, Rat (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Phospholipase Cβ4 aa. 752-961 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
