TREX1 Pure 29/TREX1 150ug
货号：
611987 基本售价：
8300.0 元 规格：
150ug
产品信息
概述| 货号 | 611987 |
| 描述 | DNA replication, repair, and recombination requires the excision of nucleotidesfrom the DNA 3 termini. Many 3 to 5 exonucleases have been identified which catalyze the excision of monophosphates from the 3 termini of DNA. TREX1 and TREX2 are 3 to 5 exonucleases that contain three conserved exonuclease active site motifs (EASM) that may produce exonuclease activity. TREX1 and TREX2 are most closely related to the proofreading exonucleases of the bacterialreplicative DNA polymerases and the RNase T enzymes. Recombinant expression of TREX1 and TREX2 demonstrates that they have exonuclease activity when oligonucleotide is present. TREX1 shows the greatest exonuclease activity with partial duplex DNA, and no activity with single-stranded RNA or an RNA-DNA partial duplex. In addition, reconstitution of TREX1 with DNA polymerase β and DNA ligase III-XRCC1 facilitates accurate rejoining of a 3 mismatched base residue at a single-strand break. Thus, TREX1 and TREX2 are 3 to 5 exonucleases that may be important for excision of nucleotides during DNA replication, repair,and recombination. |
| 同种亚型 | IgG1 |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse TREX1 aa. 82-179 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
