IRF-1 Pure 20/IRF-1 150ug
货号：
612047 基本售价：
7961.0 元 规格：
150ug
产品信息
概述| 货号 | 612047 |
| 描述 | Cytokine function is critical for both innate and adaptive immune responses. Interferon (IFN) signal transduction pathways involve a variety of transcription factors that bind specific DNA motifs called IFN-stimulated response elements (ISRE) and IFN γ-activated sequences (GAS). The IFN regulatory factor (IRF) family is a group of transcription factors that bind to these DNA motifs and regulate the activity of IFN-responsive genes. The IRF family is comprised of seven different proteins (IRF1 to IRF7) that have been identified due to their interaction with ISRE and GAS sequences. IRF1 functions in the activation of IFN-responsive genes during induction of histocompatibility antigens, and inhibition of cell proliferation. In addition, IRF1 may function as a tumor suppressor, since deletions in the IRF1 locus is associated with myelodysplasia and leukemias. IRF2 is thought to be a transcriptional repressor, while others like IRF3 and IRF4 may function as activators or repressors depending on the specific promoter. In lymphocytes, IRF4 is required for normal development and function. Thus, IRFs regulate the activity of IFN-responsive genes required for normal immune function. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human IRF1 aa. 159-279 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
