G Alp q Pure 10/GAQ 150ug
货号：
612705 基本售价：
7885.0 元 规格：
150ug
产品信息
概述| 货号 | 612705 |
| 描述 | The GTP binding regulatory proteins (G proteins) consist of three subunits: α,β , and γ . These heterotrimeric proteins function at membranes to relay signals from cell surface receptors to intracellular effectors. The α subunit is unique for each G protein and contains the site of GTP binding and hydrolysis, as well sites for receptor and effector interactions. The βγ subunit complex interacts directly with receptors and the α subunit. The G α family includes four families: the G α s family including G α s , G α o1f, and G α t, the G α i family including G α i, G α o, and G α z, the G αq/Gα 11 family and the G α 12/13 family. The G α q protein is 88% homologus with G α 11 and both are widely expressed. These G proteins activate phospholipase C proteins, which induce calcium signaling events. G protein coupled receptors (GPCRs) involved in regulating Wnt signaling activate G α q, phospholipase C β , and induce calcium-dependent activation of calpain. These events promote β -catenin nuclear export and proteolysis. G α q has also been implicated in metabotropic glutamate receptor signaling. Thus, G α q isoforms activate phospholipase C proteins in various G-protein coupled receptor pathways. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Chicken, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Gαq aa. 22-31 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
