PBK Pure 31/PBK 150ug
货号：
612171 基本售价：
7885.0 元 规格：
150ug
产品信息
概述| 货号 | 612171 |
| 描述 | Mitogen activated protein (MAP) kinase signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. The p38 MAP kinases are activated by dual phosphorylation on Thr and Tyr within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP kinase kinases, MKK3 and MKK6. PBK is a PDZ-binding Ser-Thr kinase related to the MKK3/6 MAPKK family. PBK was also identified as T-LAK cell- originated protein kinase (TOPK) and spermatogenesis-related protein kinase (SPK). PBK contains the conserved dual specficity active site sequence (D-X-K-X-X-N) at amino acids 174 to 179, and a C-terminal ETDV motif that binds PDZ domains. The mRNA expression of PBK is reportedly highest in placenta, and lower in heart and pancreas. In mitotic cells, PBK is phosphorylated and enzymatically active, and in vitro, PBK is phosphorylated by Cdc2/cyclin B. PBK can bind to the PDZ domain-containing protein, Dlg, and can phosphorylate p38 MAPK. Thus, PBKis a MAPKK family member that may be important for regulation of PDZ domain proteins during mitosis. |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) Mouse, Rat (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human PBK aa. 191-322 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
