PP5/PPT Pure 3/PP5 150ug
货号：
611021 基本售价：
7885.0 元 规格：
150ug
产品信息
概述| 货号 | 611021 |
| 描述 | Phosphorylation and dephosphorylation on serine and threonine residues is critical for signal transduction and the regulation of numerous cellular functions. Phosphorylation levels are modulated by protein kinases and phosphatases. The Ser/Thr phosphatase PP5 (also known as PPT) is a model protein of the fourth subfamily of the PPP-family of phosphatases which includes PP1, PP2A, and PP2B. PP5 is primarily located in the nucleus, demonstrates widespread tissue distribution, and is highly conserved among species. It consists of a C-terminal catalytic domain and an N-terminal TPR (tetratricopeptide repeat) domain which is involved in protein-protein interactions. The TPRs of PP5 mediate protein phosphatase activity. TPRs mediate the interaction of PP5 with various proteins including the hsp90-glucocorticoid receptor complex and the kinase domain ofANP-guanylate cyclase receptor. PP5 is thought to be important in cell growth. For example, it functions upstream of p53 to regulate p21/WAF1/Cip1-mediated G1 growth arrest. Thus, PP5 is a nuclear protein phosphatase that is involved in signaling pathways of cell growth and arrest. |
| 别名 | PPT |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Human, Mouse, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat PP5 aa. 36-238 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
