RIP2/RICK Pure 25/RIP2 150ug
货号：
612349 基本售价：
7771.0 元 规格：
150ug
产品信息
概述| 货号 | 612349 |
| 描述 | Acute promyelocytic leukemia (APL) is characterized by the translocation of the retinoic acid receptor (RAR) gene on chromosome 17q21 with the promyelocytic leukemia (PML) gene on chromosome 15q22, resulting in t(15;17). The chimeric PML-RAR α receptor protein retains essential functional domains encoded by the two genes. PML-RAR α blocks cellular differentiation, thereby inducing leukemogenesis. All-trans-retinoic acid (ATRA) induces differentiation of APL cells. It is thought that ATRA promotes PML-RAR α degredation which allows differentiation to progress. ATRA-induced differentiation of APL cells involves the coordinated regulation of many genes. NB4, a cell line derived from an APL patient, expresses RIG-G (Retinoic acid Induced Gene G) protein following treatment with ATRA or IFN- α . RIG-G displays strong homology to the protein products of the IFN-stimulated gene (ISG) family and contains multiple sites for post-translational modification. However, these sites remain to be fully characterized. Thus, RIG-G may be a component of ATRA and IFN signaling pathways that mediate cellular differentiation and the avoidance of leukemogenesis. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human RIG-G aa. 354-460 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
