PI4-Kinase Bta Pure 7 150ug
货号：
611817 基本售价：
7771.0 元 规格：
150ug
产品信息
概述| 货号 | 611817 |
| 描述 | Phosphoinositide turnover is a well established mechanism of intracellular signal transduction. Sequential phosphorylation of phosphatidylinositol (PtdIns) results inPtdIns-4-phosphate (PIP) and PtdIns-4,5-bisphosphate (PIP2). Phospholipase C (PLC)hydrolyzes PIP2 to inositol-1,4,5-trisphosphate (IP3) which stimulates release of intracellular Ca2+. PIP is generated by phosphorylation of PtdIns at the D4 position of the inositol ring. This event is mediated by the PtdIns4-k inases (PI4-K). These enzymes are divided into two types (II and III) based on their size and sensitivity to certain compounds. Although the PI4-Ks are abundantly distributed throughout the cell, activity is found primarily in association with membranous structures. Members of this family contain a lipid kinase unique domain and a C-terminal catalytic domain. Two mammalian PI4-Ks, PI4-K α and PI4-Kß, have been identified. PI4-Kß is homologous to the yeast PI4-K, PIK1. Based on its size and sensitivity to wortmanin (a PI3-K inhibitor), PI4-Kß is classified as a type III enzyme. Although it is found in the cytosol and in association with the Golgi, the specific function of PI4-Kß is yet to be determined. |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human PI4Kβ aa. 411-626 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
