NF-KpaB p65 Pure 20NF-KpaB/p65 150ug
货号：
610869 基本售价：
7771.0 元 规格：
150ug
产品信息
概述| 货号 | 610869 |
| 描述 | NF-κ B is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. The most studied NF- κ B complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF- κ B with its inhibitor, I κ B. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to I κ B. This complex prevents nuclear translocation and activity of NF- κ B. In response to stimuli such as cytokines, LPS, and viral infections, I κ B is phosphorylated at critical residues. This phosphorylation induces dissociation of the I κB/NF-κ B complex, allowing the free heterodimeric NF- κ B to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the κ B site within promoters and enhancers and functions as a transcriptional activator. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Rat, Dog, Frog, Rabbit (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human NF-κB aa. 136-224 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
