GSK-3 Bta Pure 7/GSK-3b 150ug
货号：
610202 基本售价：
7771.0 元 规格：
150ug
产品信息
概述| 货号 | 610202 |
| 描述 | Glycogen Synthase Kinase-3 β(GSK-3β ) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and, thus, down-regulating the activity of muscle glycogen synthase. GSK-3 β is identical to the Tau Protein Kinase 1 (TPK 1) which plays a role in the formation of the histopathological lesions of Alzheimers disease (AD). In AD, many neurons contain intracytoplasmic neurofibrillary tangles (NFT) that are composed of ubiquitin and highly phosphorylated tau proteins, members of a family of microtubule-assocaited phosphoproteins. Phosphorylation of the tau proteins by GSK-3 β converts them into paired helical filaments (PHF) which are found in NFT and degenerative neurites of senile plaques. This ability of GSK-3 β to convert tau proteins to PHF has been demonstrated in vitro using primary cultures of embryonic rat hippocampal neurons. |
| 同种亚型 | IgG1 |
| 反应种属 | Mouse (QC Testing) Human, Rat, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IHC, IP, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat GSK-3β aa. 1-160 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
