Phospholipase Cgma1 Pure 10/PLCgma 150ug
货号：
610028 基本售价：
7771.0 元 规格：
150ug
产品信息
概述| 货号 | 610028 |
| 描述 | The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLC g is the only member that contains SH2 and SH3 domains. These domains enable it to interact with receptor tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: 1) PLC g 1, which is ubiquitously expressed, and 2) PLC g 2, found primarily in the lymphoid system. PLC g is essential for growth factor-induced cell motility and mitogenesis. PLC g 1 null mice exhibit retarded embryonic growth and lethality in midgestation. Overexpression of PLC g is evident in several forms of cancer, and it has been identified as a key mediator of PDGF-dependent cellular transformation. Thus regulation of PLC g activity by growth factors is involved in cell growth and transformation. The 10/PLCgamma monoclonal antibody recognizes PLC g 1, regardless of phosphorylation status. It does not cross-react with PLC g2. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IHC, IP, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Cow PLCγ1 N-terminal region Peptide |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
