SATB1 Alexa 647 14/SATB1 100Tst
货号：
562378 基本售价：
6825.0 元 规格：
100Tst
产品信息
概述| 货号 | 562378 |
| 描述 | The 14/SATB1 monoclonal antibody specifically binds to the special AT-rich sequence binding protein 1 that is encoded by the SATB1 (SATB homeobox 1) gene. Central to the formation of nucleosomes, which consist of octameric histone cores with defined segments of chromatin wound around them, are the interactions of nucleosomes with nuclear matrix components. Specific genomic DNA segments that interact with the nuclear matrix are called scaffold or matrix attachment regions (SARs or MARs). SATB1 is a homeodomain MAR binding protein. It recognizes ATC sequences that consist of stretches of As, Ts, and Cs on one DNA strand. SATB1 is expressed by thymocytes (especially single positive CD4+ thymocytes), T and B lymphocytes, NK cells, and macrophages. SATB1 can recruit chromatin-remodeling factors and thereby regulate chromatin structure and gene expression. Recently it has been reported that repression of SATB1 was essential for the phenotype and function of mouse regulatory T cells but inhibitory for the establishment of transcriptional programs expressed by effector T cells. |
| 别名 | SATB homeobox 1; Special AT-rich sequence-binding protein 1 |
| 同种亚型 | Mouse IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human SATB1 aa. 550-667 |
| 标记 | Alexa Fluor 647 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
