Ronin/THAP11 Pure P56-507 100ug
货号：
562548 基本售价：
5500.0 元 规格：
100ug
产品信息
概述| 货号 | 562548 |
| 描述 | Thanatos-associated proteins (THAPs) are characterized by the THAP domain, which is a conserved Drosophila P element transposase DNA-binding domain. THAPs are DNA-binding factors involved in cell proliferation, apoptosis, cell cycle and transcriptional regulation. THAP11 is an essential factor in embryogenesis and ES cell pluripotency and binds directly to host cell factor 1 (HCF-1), a key regulator of transcriptional control. THAP11 has been designated as Ronin, named for a masterless Japanese samurai because of its lack of any apparent relationship to Nanog, Oct4 and Sox2the master regulators of pluripotency. Ronin/THAP11 binds to the c-Myc promoter and down-regulates c-Myc expression. Recently, it was reported that Bcr-Abl inhibited the expression of THAP11 in Chronic myelogenous leukemia (CML) cells and promoted CML cell proliferation by the aberrant induction of c-Myc expression. |
| 别名 | Ronin, THAP11 |
| 同种亚型 | Mouse IgG2b, κ |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Ronin/THAP11 Recombinant Protein |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
