CNTFRAlp Pure AN-H6 100ug
货号：
558783 基本售价：
5282.0 元 规格：
100ug
产品信息
概述| 货号 | 558783 |
| 描述 | Ciliary neurotrophic factor receptor (CNTFR) shares functional and structural properties with members of the hematopoietic cytokine family. Signaling through the CNTFR involves the binding and activation of a multisubunit receptor complex composed of three components: a ligand-specific-α-receptor (CNTFRα), signal-transducing β-subunits of gp130 and leukemia inhibitory factor receptor-β (LIFR). Binding of CNTF to CNTFR triggers the association of the receptor complex components resulting in activation of a signal transduction cascade mediated by intracellular protein tyrosine kinases. CNTFR can function in a membrane-bound or soluble form; the membrane-bound form is expressed in neuronal and muscle cells, while the soluble form, once processed, can serve as a cofactor to potentiate CNTF actions. This action may serve to enhance the survival, proliferation, and maturation of oligodendrocyte lineage cells. AN-H6 recognizes human and mouse CNTFRα. The antibody is routinely tested by western blot analysis on L929 cells transfected with CNTFRα. The 40 and 60 kDa proteins are thought to represent the non-glycosylated and glycosylated forms of the CNTFRα, respectively. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
