PRK Pure B37-2 100ug
货号：
556518 基本售价：
5282.0 元 规格：
100ug
产品信息
概述| 货号 | 556518 |
| 描述 | PRK (proliferation-related kinase) is a serine/threonine kinase with significant homology to members of the polo family of protein kinases (e.g., mouse fnk/snk, human and mouse plk). There are two domains in the polo family kinases, an amino-terminal kinase domain and a carboxylterminal regulatory domain. Polo kinases have been previously implicated in cell division. Tissue specific expression of PRK mRNA is normally fairly restricted, but includes human placenta, and to a lesser degree, ovaries and peripheral blood leukocytes. PRK mRNA is generally undetectable in many cell lines but may be induced in some cell types by mitogens or following addition of serum to previously serum-deprived cells. PRK expression is tightly regulated at various levels during different stages of the cell cycle. For example, PRK kinase activity in lung fibroblasts is relatively low during mitosis, G1, and G1/S; PRK activity peaks in late S and G2. Recombinant human PRK is capable of phosphorylating Cdc25C, a positive regulator for the G2/M transition. Thus, PRK appears to play an important role in regulating the onset and/or progression of mitosis in mammalian cells. PRK was originally reported to migrate at 68 kD in SDS-PAGE. We observe that PRK migrates at ~72 kD. A recombinant protein corresponding to amino acids 334 to 607 of human PRK was used as immunogen. |
| 别名 | Proliferation Related Kinase |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant Human PRK Protein aa. 334-607 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
