Fos Pure G54-9.9 100ug
货号：
554156 基本售价：
5282.0 元 规格：
100ug
产品信息
概述| 货号 | 554156 |
| 描述 | The cellular fos protein (c-fos) and its viral counterpart v-fos belong, along with fosB, fra-1, and fra-2, to the fos family of transcription factors. They are related to other transcription factor families such as the jun proteins (e.g., CREB, DBP, and C/EBB) with which they share a conserved basic domain (DNA binding motif) and a leucine zipper domain. Whereas jun proteins can form homodimers that act as transcriptional activators, fos proteins only form heterodimers, preferentially with jun proteins. The transcription factor AP-1, which selectively binds to enchancer elements in the promoter region of a wide variety of genes, is a heterodimer of c-fos and c-jun. Deletion analyses and mutagenesis studies have shown that the leucine zipper region from fos and jun is necessary for selective heterodimer formation. c-fos appears primarily as a 55 kDa protein on SDS-polyacrylamide gels; however, it undergoes post-translational modification and other forms have been described including 57 kDa, 60 kDa, and 62 kDa. Clone G54-9.9 recognizes mouse and human c-fos as single or multiple bands (55-62 kDa). Reactivity to fos proteins of other species has not yet been tested. Mice were immunized with a fos specific fragment (amino acid residues 73-152) of the FBJ-MSV v-fos protein. The region excludes completely the DNA binding and leucine zipper motifs. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, GS, IP |
性能| 供应商 | BD Pharmingen |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
