Nogo-A Pure 17/Nogo-A 50ug
货号：
612238 基本售价：
4140.0 元 规格：
50ug
产品信息
概述| 货号 | 612238 |
| 描述 | During neural development, many axons must travel long distances before reaching their dendritic targets and establishing synapses. After injury, these axonal connections can only regenerate in the peripheral nervous system, but not in the central nervous system (CNS). This difference in axon regeneration is thought to involve various inhibitory molecules found in the myelin of axons in the CNS. Nogo was identified in assays that examined fractions from myelin extracts for the antigen of monoclonal antibody IN-1, an antibody that allows modest axon regeneration after spinal cord injury. Nogo is expressed as three different proteins, Nogo-A, -B, and -C, which are members of the Reticulon family of ER anchoring proteins. Nogo-A is the full length protein, while Nogo-B contains 172 amino acids of the N-terminus and 188 amino acids of the C-terminus of Nogo-A, and Nogo-C contains only the 188 amino acid C-terminus of Nogo-A. These splice variants are all found in optic nerve, spinal cord, and cerebral cortex, but differ in expression in other neuronal and non-neuronal tissues. Thus, Nogo-A is a myelin-associated protein that may have roles in the ER, as well as during axon regeneration. |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat Nogo-A aa. 424-627 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
