SHIP-1 Pure 32/SHIP-1 50ug
货号：
611334 基本售价：
4140.0 元 规格：
50ug
产品信息
概述| 货号 | 611334 |
| 描述 | Tyrosine kinase receptors control the growth, survival, differentiation, and expression of mature hematopoietic cell functions. Activation of these receptors leads to Tyr phosphorylation of specific residues that are bound by SH-2 domain containing proteins like GRB2, SHC, p85/PtdIns-3-kinase, or SH2-containing inositol phosphatases (SHIPs). These adaptor proteins regulate the activity of downstream effectors either through interaction with SH-3 domains or through enzymatic modification. SHIPs include SHIP-1 (p150[Ship]) and SHIP-2. SHIP-1 is an inositol polyphosphate-5-phosphatase that contains one SH2 domain, two potential phosphotyrosine-binding domains, an ATP/GTP-binding domain, and several potential SH-3-binding sites. It is co-expressed in spleen, thymus, and lung with SHIP-2. While SHIP-1 is involved in negative regulation of macrophage cell growth, it functions in B cell activation. Thus, through interactions with other adaptor proteins or its enzymatic function, SHIP-1 is an essential component of receptor tyrosine kinase pathways that control hematopoietic cell function. |
| 别名 | p150[SHIP] |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse p150 [SHIP] aa. 16-135 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
