Utrophin Pure 55/Utrophin 50ug
货号：
610896 基本售价：
4140.0 元 规格：
50ug
产品信息
概述| 货号 | 610896 |
| 描述 | Utrophin is an autosomal homolog of dystrophinlocated on chromosome 6q24. Both encode large cytoskeletal proteins that are members of the spectrin superfamily. Spectrin family proteins are located at the cytoplasmic face and link the intracellular cytoskeleton to the extracellular matrix. Utrophin is nearly identical to dystrophin, specifically in the N-terminal actin binding domain and the C-terminus. Dystrophin is expressed primarily in the brain and muscle, while Utrophin is ubiquitously expressed. In skeletal muscle, Utrophin expression varies depending on the the state of differentiation and innervation of muscle fibers. During development, it localizes in the sarcolemma. Following formation of synaptic contacts, Utrophin is found within the postsynaptic membrane domain of the neuromuscular junction. However, its expression is not limited to postsynaptic compartments. Although dystrophin is absent in patients with Duchenne muscular dystrophy (DMD) and mdx (dystrophin deficient) mice, Utrophin is upregulated. The regulation mechanisms underlying Utrophin expression in muscle have yet to be determined. |
| 同种亚型 | IgG1 |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse Utrophin aa. 768-874 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
