HIF-1 ALPHA ALEXA 647 54 50UG
货号：
565924 基本售价：
3995.0 元 规格：
50ug
产品信息
概述| 货号 | 565924 |
| 描述 | The 54/HIF-1 α monoclonal antibody specifically recognizes the alpha subunit (HIF-1alpha/HIF-1a/HIF1A) of the heterodimeric helix-loop-helix transcription factor, Hypoxia-induced factor 1 (HIF-1) complex which is involved in cellular O2 homeostasis. Under hypoxic conditions, HIF-1a accumulates and translocates into the nucleus, where it binds to the constitutively-expressed HIF-1 beta subunit (HIF-1b, also known as, Aryl hydrocarbon receptor nuclear translocator/ARNT). This complex can then bind to hypoxic response elements (HREs) of target genes, including glucose transporters, glycolytic enzymes, erythropoietin, vascular endothelial growth factor (VEGF), and various other genes that facilitate metabolic adaptation to hypoxia. HIF-1a is also known to be regulated by proinflammatory cytokines and bacterial products and plays an essential role in inflammation, immunity, and cancer. HIF-1a is rapidly degraded under normoxic conditions. |
| 别名 | HIF1; HIF-1A; HIF1A; HIF-1-alpha; HIF1-alpha; BHLHE78; MOP1; PASD8 |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human HIF-1α aa. 610-727 |
| 标记 | Alexa 647 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
