eIF-6 Pure 23/eIF-6 50ug
货号：
611120 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 611120 |
| 描述 | Initiation of eukaryotic translation involves a series of reactions mediated by multiple eukaryotic initiation factors (eIFs). As a prerequisite to initiation, the initiator methionyl-tRNA (Met-tRNAf), in a ternary complex with eIF-2 and GTP, binds to the 40S ribosomal subunit. This 40S preinitiation complex is positioned at the initiation AUG codon to form the 40S initiation complex. This complex is joined by the 60S ribosomal subunit to form the 80S initiation complex, which functions as a peptidyl transferase. Once translation is completed, the polysomal complex is dismantled with the formation of the free 40S and 60S subunits. eIF-6 is a monomeric protein which binds to the 60S ribosomal subunit and blocks its association with the 40S subunit. The human eIF-6 is expressed in a wide range of tissues and exhibits a significant homology with sequences from S. cerevisiae andDrosophila. The joining of the 60S subunit to the 40S initiation complex requires eIF-5; thus, eIF-5 & -6 may maintain equilibrium between the individual subunits and the 80S complex. |
| 别名 | Eukaryotic Initiation Factor-6 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human eIF-6 aa. 17-128 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
