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货号： bs-6459R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6459R-HRP
- 英文名称
- Anti-hnRNP C1/C2/HRP
- 中文名称
- 辣根过氧化物酶标记的异质性核糖核蛋白C1/C2抗体
- 别 名
- hnRNP C1 + C2; Heterogeneous nuclear ribonucleoprotein C; Heterogeneous nuclear ribonucleoproteins C1/C2; HNRNP; hnRNP C1 / hnRNP C2; hnRNPC; HNRPC; HNRPC_HUMAN; Nuclear ribonucleoprotein particle C1 protein; Nuclear ribonucleoprotein particle C2 protein; SNRPC.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HNRPC
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3-UTR or 5-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.
Function:
UniProtKB/Swiss-Prot: P07910.4
Subunit:
Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1.
Subcellular Location:
Nucleus. Component of ribonucleosomes.
Post-translational modifications:
Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
Sumoylated. Sumoylation reduces affinity for mRNA.
Similarity:
Belongs to the RRM HNRPC family. RALY subfamily.
Contains 1 RRM (RNA recognition motif) domain.
Database links:Entrez Gene: 3183Human
Entrez Gene: 15381Mouse
Entrez Gene: 290046Rat
Omim: 164020Human
SwissProt: P07910Human
SwissProt: Q9Z204Mouse
SwissProt: P17132Rat
Unigene: 508848Human
Unigene: 675546Human
Unigene: 427321Mouse
Unigene: 473169Mouse
Unigene: 101929Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.