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货号： bs-9107R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9107R-HRP
- 英文名称
- Anti-POP1/HRP
- 中文名称
- 辣根过氧化物酶标记的感染性蛋白唯一蛋白1抗体
- 别 名
- PAAD domain only protein; POP1; PYDC1; Pyrin domain containing 1; Pyrin only protein 1; PYDC1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 10kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ASC2/POP1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes.
Function:
Associates with apoptosis-associated specklike proteincontaining a CARD domain (ASC) and modulates its ability tocollaborate with pyrin and cryopyrin in NF-kappa-B andpro-caspase-1 activation. Suppresses kinase activity of NF-kappa-Binhibitor kinase (IKK) complex, expression of NF-kappa-B induciblegenes and inhibits NF-kappa-B activation by cytokines and LPS.
Subunit:
Interacts with PYCARD/ASC.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in monocytes,macrophages and granulocytes.
Post-translational modifications:
Phosphorylated.
Similarity:
Contains 1 DAPIN domain.
Database links:
UniProtKB/Swiss-Prot: Q8WXC3.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.