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货号： bs-9716R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9716R-PE
- 英文名称
- Anti-KBP/PE
- 中文名称
- PE标记的KBP蛋白抗体
- 别 名
- Hypothetical protein LOC26128; KBP; KBP_HUMAN; KIAA1279; KIF1-binding protein; TTC20; Uncharacterized protein KIAA1279.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导 细胞周期蛋白 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 72kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KBP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Chromosome 10 contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious. The KIAA1279 gene product has been provisionally designated KIAA1279 pending further characterization.
Function:
Required for organization of axonal microtubules, andaxonal outgrowth and maintenance during peripheral and centralnervous system development. Regulates mitochondrial transport bymodulating KIF1B motor activity.
Subunit:
Interacts with KIF1B.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Highly expressed in heart, brain, ovary, testis, spinal cord and all specific brain regions examined. Moderate expressed at intermediate level in all other adult tissues examined, as well as in fetal liver and brain. Not expressed in blood leukocytes.
DISEASE:
Defects in KIAA1279 are the cause of Goldberg-Shprintzenmegacolon syndrome (GOSHS) [MIM:609460]. GOSHS is characterized bymicrocephaly, mental retardation and facial dysmorphism, as well asphenotypes related to Hirschsprung disease syndrome.
Similarity:
Belongs to the KIF1-binding protein family.
Database links:Entrez Gene: 100063227 Horse
Entrez Gene: 26128 Human
Entrez Gene: 72320 Mouse
Entrez Gene: 606294 Rat
Omim: 609367 Human
SwissProt: Q96EK5 Human
SwissProt: Q6ZPU9 Mouse
SwissProt: Q4G074 Rat
Unigene: 279580 Human
Unigene: 258955 Mouse
Unigene: 100975 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.