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货号： bs-9759R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9759R-PE
- 英文名称
- Anti-CAP/PE
- 中文名称
- PE标记的染色体相关蛋白CAP抗体
- 别 名
- Brd4; BRD4_HUMAN; bromodomain containing protein 4; Bromodomain-containing protein 4; CAP; chromosome associated protein; HUNK1; Protein HUNK1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 152kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Brd4/CAP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Brd4 belongs to the BET family, a group of structurally related proteins containing two bromodomains. Through these two domains, Brd4 associates with mitotic chromosomes and its expression correlates with cell growth. Expression of Brd4 inhibits cell cycle progression from G(1) to S, due to binding to the largest subunit of replication factor C (RFC) to prevent DNA elongation. Altered Brd4 function correlates with poorly differentiated carcinoma, with aggresive phenotype and a highly lethal outcome.
Function:
Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
Subunit:
Associated with chromosomes during mitosis. Interacts with bovine papillomavirus type 1 regulatory protein E2.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed.
DISEASE:
Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.
Similarity:
Contains 2 bromo domains.
Database links:Entrez Gene: 10487 Human
Entrez Gene: 12331 Mouse
Entrez Gene: 64185 Rat
SwissProt: Q01518 Human
SwissProt: P40124 Mouse
SwissProt: Q08163 Rat
Unigene: 370581 Human
Unigene: 713078 Human
Unigene: 8687 Mouse
Unigene: 112585 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.