Porcine IL-2 Allophycocyanin MAb (Clone 100312) (100 TESTS)【科瑞奥博】

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Porcine IL-2 Allophycocyanin MAb (Clone 100312) (100 TESTS)

货号： IC6521A 基本售价： 4659.8 元规格： 100 Tests

产品信息

概述
货号	IC6521A
别名	aldesleukin; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF
全称	Interleukin 2
反应种属	Porcine
应用	Intracellular Staining by Flow Cytometry
目标/特异性	Detects porcine IL-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with human, mouse, rat, bovine, canine, equine, feline, or cotton rat IL-2 is observed.
使用方法	Intracellular Staining by Flow Cytometry: 10 µL/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant porcine IL-2 Ala21-Thr154 Accession # P26891
生物活性	Porcine
标记	Allophycocyanin
背景	IL-2 is a 15-19 kDa secreted O-glycosylated polypeptide that belongs to the gamma _c -receptor utilizing family of molecules. It is a monomer that is expressed by a limited number of cell types, including CD4⁺ and CD8⁺ T cells, gamma δ T cells, eosinophils, endothelial cells, and B cells. Its local concentration, plus the stoichiometry of it receptor ( a two or three subunit complex) appears to determine what effects it has on its target cells. It is suggested to both induce NK and CD8⁺ T cell proliferation, and promote NK cell and CD8⁺ T cell effector activity. IL-2 also appears to drive CD4⁺ Fox P3^- thymocytes into mature FoxP3⁺ Tregs, and to direct the conversion of CD4⁺ T cells into induced Tregs. Finally, IL-2 induces gamma δ T cells to secrete IFN-gamma, and endothelial cells to upregulate endocytic activity. Mature porcine IL-2 shares 71% and 51% amino acid sequence identity with human and mouse IL-2, respectively.
运输条件	Blue Ice
存放说明	4℃
参考文献	BIObrief: Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Cancer Biomarkers Common gamma Chain Receptor Family Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Conventional/Classical Dendritic Cells Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Tfh Cell Differentiation and Function gamma delta T Cells Group 1 ILCs ICC / IHC Images: IL-2 Infectious Diseases Inflammatory Mediators Interactive Pathway: IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-2 Signaling Pathways Isolation, Culture, and Identification of Natural Killer Cells Mini-review: Cytolytic Granule-mediated Apoptosis Multiple Sclerosis and Myelin Related Molecules NCR+ILC3 Neuroinflammation Preeclampsia Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th1 Cells Th2 Cells Th9 Cells

参考图片

Detection of IL‑2 in Porcine PBMCs by Flow Cytometry. Porcine peripheral blood mononuclear cells stimulated with LPS were stained with Mouse Anti-Porcine IL‑2 APC‑conjugated Monoclonal Antibody (Catalog # IC6521A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Intracellular Molecules.