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货号： bs-9879R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9879R-PE
- 英文名称
- Anti-protein 4.2/PE
- 中文名称
- PE标记的红细胞膜蛋白4.2抗体
- 别 名
- protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞表面分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 77kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human EPB42/protein 4.2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
protein 4.2;protein4.2; EPB42;EPB42_HUMAN;Erythrocyte membrane protein band 4.2;Erythrocyte protein 4.2;Erythrocyte surface protein band 4.2;MGC116735;P4.2;PA;SPH5.
Function:
Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
Subunit:
Oligomer. Interacts with the cytoplasmic domain of SLC4A1/band 3 anion transport protein.
Subcellular Location:
Cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes.
Post-translational modifications:
Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.
DISEASE:
Defects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
Similarity:
Belongs to the transglutaminase superfamily. Transglutaminase family.
Database links:Entrez Gene: 2038 Human
Omim: 177070 Human
SwissProt: P16452 Human
Unigene: 368642 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Involvement in disease:Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.