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货号： bs-9895R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9895R-PE
- 英文名称
- Anti-Cappuccino/PE
- 中文名称
- PE标记的Cappuccino蛋白抗体
- 别 名
- Cappuccino; Cappuccino homolog; Cappuccino homolog; FLJ11230; Protein cappuccino; Protein cappuccino homolog; BL1S4_HUMAN; Biogenesis of lysosome-related organelles complex 1 subunit 4; BLOC-1 subunit 4; BLOC1S4; BCAS4L; CNO.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Cappuccino
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a multisubunit protein necessary for biogenesis of specialized organelles of the endosomal-lysosomal system (such as melanosomes and platelet-dense granules). The complex consists of coiled-coil-forming proteins Snapin, Pallidin, Cappuccino, Muted, BLOS1, BLOS2, and BLOS3. The localization of these proteins varies as they can be cytoplasmic, peripheral membrane bound or anchored to the vesicular membrane.Cappuccino, a primarily cytoplasmic protein, plays a role in the development of melanosomes, platelet-dense granules and other lysosome-related organelles. It interacts primarily with pallidin and Muted and has been implicated as an actin-nucleation factor that may play a role in crosstalk between microfilaments and microtubules.
Function:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Subunit:
Interacts with BLOC1S5 and BLOC1S6. Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos.
Subcellular Location:
Cytoplasmic.
Tissue Specificity:
The intronless CNO (Cappuccino) gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mouse CNO is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The CNO protein may play a role in intracellular vesicular trafficking.
Similarity:
Cytoplasm.
Database links:Entrez Gene: 55330 Human
Omim: 605695 Human
SwissProt: Q9NUP1 Human
Unigene: 7570 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.