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货号： bs-4834R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4834R-PE
- 英文名称
- Anti-CD73/PE
- 中文名称
- PE标记的CD73抗体
- 别 名
- NT5; 5 NT; 5 nucleotidase (CD73); 5 nucleotidase precursor; 5 nucleotidase, ecto; 5 nucleotidase, ecto (CD73); 5-NT; 5-nucleotidase; 5-nucleotidase; 5NTD_HUMAN; CD73; CD73 antigen; E5NT; Ecto 5 nucleotidase; Ecto-5-nucleotidase; eN antibody eNT; NT antibody NT5; NT5E; NTE; Purine 5 Prime Nucleotidase.
- JournalPMIDIFApplicationBMC veterinary research (2012)229378621.8600FACS
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 免疫学 细胞粘附分子 细胞表面分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse,
- 产品应用
- Flow-Cyt=1:20-500 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 63kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CD73/NT5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
CD73 is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins.
Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Subcellular Location:
Cell membrane.
DISEASE:
Defects in NT5E are the cause of calcification of joints and arteries (CAJA). A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands.
Similarity:
Belongs to the 5-nucleotidase family.
Database links:Entrez Gene: 4907Human
Omim: 129190Human
SwissProt: P21589Human
Unigene: 153952Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.