Pig CD8A Alexa 647 76-2-11 50ug
货号：
561475 基本售价：
2640.0 元 规格：
50ug
产品信息
概述| 货号 | 561475 |
| 描述 | The 76-2-11 (also known as clone PT8) monoclonal antibody specifically binds to an epitope on the CD8 α chain, a 35-kDa antigen expressed on thymocytes, peripheral T lymphocytes, and NK cells. The CD8 molecule can exist as a 70 kDa homodimer, composed of α chains, or heterodimer, composed of an αandβ chain. Cells which express the CD8 αα homodimer display dimmer staining with mAb 76-2-11 than CD αβ -expressing cells. The 76-2-11 mAb does not cross-react with human or bovine cells. Two peripheral CD8+ T-cell populations can be distinguished in the pig: CD8-bright CD4- CTL effectors/precursors and CD8-dull CD4+ T-helper lymphocytes. Pig NK cells express CD8 (dull staining), CD2, MHC class II, LFA-1, and asialo-GM1, but not CD3, CD4, CD5, or CD6. mAb 76-2-11 has been reported to partially inhibit in vitro cytotoxic activity of PBL to allogeneic leukocytes, but not NK-cell-mediated lysis, and to deplete CD8+ T cells in vivo . This clone was clustered as anti-CD8a at the First International Swine CD workshop. |
| 同种亚型 | Mouse BALB/c IgG2a, κ |
| 反应种属 | Pig (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | dd miniature swine thymocytes |
| 标记 | Alexa Fluor 647 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
