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货号： bs-11354R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11354R-PE
- 英文名称
- Anti-Piccolo/PE
- 中文名称
- PE标记的神经细胞突触蛋白PCLO抗体
- 别 名
- ACZ; Aczonin; Brain-derived HLMN protein; DKFZp779G1236; KIAA0559; Multidomain presynaptic cytomatrix protein; PCLO; PCLO_HUMAN; Piccolo (presynaptic cytomatrix protein); Piccolo, mouse, homolog of antibody Pico; Presynaptic cytomatrix protein; Protein piccolo.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 557kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Piccolo
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Piccolo is 1 component of the presynaptic cytomatrix. Bassoon is a large protein which is also found in the presynaptic compartments of rat brain synapses. Bassoon, along with Piccolo, is part of the ensemble of presynaptic proteins that are involved in orchestrating events at the nerve terminal. Bassoon is found in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone. Piccolo has a similar distribution and colocalizes with Bassoon in cultured hippocampal cells. Piccolo zinc fingers interact with the dual prenylated rab3A and VAMP2/ Synaptobrevin II receptor PRA. Bassoon may be involved in cytomatrix organization at the site of neurotransmitter release. The gene which encodes bassoon maps to human chromosome 3p21.31. The gene which encodes piccolo maps to human chromosome 7q21.11.
Function:
May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.
Subunit:
Interacts with RABAC1/PRA1, RIMS2 and profilin (By similarity).
Subcellular Location:
Cell junction, synapse. Note=Concentrated at the presynaptic side of synaptic junctions.
Similarity:
Contains 2 C2 domains.
Contains 1 PDZ (DHR) domain.
Database links:Entrez Gene: 27445 Human
Entrez Gene: 26875 Mouse
Entrez Gene: 56768 Rat
Omim: 604918 Human
SwissProt: Q9Y6V0 Human
SwissProt: Q9QYX7 Mouse
SwissProt: Q9JKS6 Rat
Unigene: 12376 Human
- Unigene: 146275 Mouse
- Unigene: 53925 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.