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货号： bs-11504R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11504R-PE
- 英文名称
- Anti-ATRNL1/PE
- 中文名称
- PE标记的ATRNL1蛋白抗体
- 别 名
- ATRN1_HUMAN; ATRNL1; Attractin-like protein 1; KIAA0534.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 147kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ATRNL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ATRNL1 is a 1,379 amino acid single-pass type I membrane protein that may play a role in melanocortin signaling pathways that regulate energy homeostasis. The ATRNL1 protein contains a C-type lectin domain, a CUB domain, two EGF-like domains, six Kelch repeats, two laminin EGF-like domains and five PSI domains. ATRNL1 interacts with MC4-R in several regions known to be important in the regulation of energy homeostasis by melanocortins, such as the paraventricular nucleus of hypothalamus and the dorsal motor nucleus of the vagus. The ATRNL1 gene is conserved in dog, cow, mouse, rat, chicken, zebrafish and C. elegans, exists as two alternatively spliced isoforms and maps to human chromosome 10q25.3. Strong evidence of linkage to late-onset Alzheimer disease (LOAD) is linked to chromosome 10, which implicates a wide region and at least one disease-susceptibility locus.
Function:
May play a role in melanocortin signaling pathways that regulate energy homeostasis.
Subunit:
Interacts with MC4R
Subcellular Location:
Membrane; Single-pass type I membrane protein
Similarity:
Contains 1 C-type lectin domain.
Contains 1 CUB domain.
Contains 2 EGF-like domains.
Contains 6 Kelch repeats.
Contains 2 laminin EGF-like domains.
Contains 5 PSI domains.
Database links:
UniProtKB/Swiss-Prot: Q5VV63.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.