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货号： bs-11582R-PE 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11582R-PE
- 英文名称
- Anti-RAPGEF5/Repac/PE
- 中文名称
- PE标记的Rap鸟嘌呤核苷酸交换因子(GEF)5抗体
- 别 名
- GFR; Guanine nucleotide exchange factor for Rap1; KIAA0277; M Ras regulated Rap GEF; M-Ras-regulated Rap GEF; MR GEF; MR-GEF; MRGEF; Rap guanine nucleotide exchange factor 5; Rapgef5; Related to Epac; Repac; RPGF5_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 神经生物学 信号转导 转录调节因子 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RAPGEF5 (151-250aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Function:
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed with highest levels in brain.
Similarity:
Contains 1 N-terminal Ras-GEF domain.
Contains 1 Ras-GEF domain.
Database links:Entrez Gene: 9771Human
Entrez Gene: 217944Mouse
Entrez Gene: 362799Rat
Omim: 609527Human
SwissProt: Q92565Human
SwissProt: Q8C0Q9Mouse
SwissProt: P83900Rat
Unigene: 174768Human
Unigene: 713217Human
Unigene: 227642Mouse
Unigene: 22381Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.