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货号： bs-20750R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20750R-Cy7
- 英文名称
- Anti-UCP-2/Cy7
- 中文名称
- Cy7标记的线粒体脱偶连蛋白2抗体
- 别 名
- Uncoupling Protein-2; UCP2; UCP 2; BMIQ4; Mitochondrial uncoupling protein 2; SLC25A8; UCPH; Uncoupling protein 2; Uncoupling protein 2 mitochondrial proton carrier; Solute carrier family 25 member 8; UCP2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 染色质和核信号 糖尿病
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human UCP-2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes.
Function:
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Subunit:
Acts as a dimer forming a proton channel (By similarity).
Subcellular Location:
Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.
Similarity:
Belongs to the mitochondrial carrier family.
Contains 3 Solcar repeats.
Database links:Entrez Gene: 7351 Human
Entrez Gene: 54315 Rat
Omim: 601693 Human
SwissProt: P55851 Human
SwissProt: P56500 Rat
Unigene: 80658 Human
Unigene: 13333 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
UCP-2又称解耦联蛋白 2 (UCP2 )是 1997年发现的一种新的解偶联蛋白 ,它是线粒体内膜载体家族的一员 。与其类似物UCP1相比 ,UCP2在棕色脂肪组织中含量较低 ,但在体内分布广泛。解耦联蛋白(UCP)具有使线粒体呼吸链解耦联作用,解耦联所释放的能量以热能的形式散发。在对UCP与产热关系的研究中,发现UCP2具有调节机体能量代谢的功能,并且可能是肥胖与2型糖尿病相关联的一个重要基因。