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货号： bs-6989R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6989R-HRP
- 英文名称
- Anti-G6PDH/HRP
- 中文名称
- 辣根过氧化物酶标记的己糖6磷酸脱氢酶抗体
- 别 名
- 6 phosphogluconolactonase; 6-phosphogluconolactonase; 6PGL; H6PD; DKFZp686A01246; G6PD H form; G6PDH; G6PE_HUMAN; GDH; H6PD; GDH/6PGL endoplasmic bifunctional protein; Glucose 1 dehydrogenase; Glucose 6 phosphate dehydrogenase salivary; Glucose dehyrogenase; Gpd1; H6pd; Hexose 6 phosphate dehydrogenase; Hexose-6-phosphate dehydrogenase; MGC87643.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 85kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human G6PDH
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
H6PD (hexose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein) is a 789 amino acid protein encoded by the human gene H6PD. The N-terminal section of H6PD belongs to the glucose-6-phosphate dehydrogenase family, while the C-terminal section belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily. H6PD is responsible primarily for the oxidation of glucose-6-phosphate and glucose. It also oxidizes other hexose-6-phosphates. H6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor for the reductase activity of 11∫-hydroxysteroid dehydrogenase type 1, which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone).
Function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Subcellular Location:
Endoplasmic reticulum lumen. Note=Microsomes, endoplasmic reticulum lumen.
Tissue Specificity:
Present in most tissues examined, strongest in liver.
DISEASE:
Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Similarity:
In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.
In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Database links:Entrez Gene: 25796 Human
Entrez Gene: 9563 Human
Entrez Gene: 100198 Mouse
Entrez Gene: 66171 Mouse
Entrez Gene: 290636 Rat
Entrez Gene: 298655 Rat
Omim: 138090 Human
Omim: 604951 Human
SwissProt: O95336 Human
SwissProt: O95479 Human
SwissProt: Q8CFX1 Mouse
SwissProt: Q9CQ60 Mouse
SwissProt: P85971 Rat
Unigene: 463511 Human
Unigene: 466165 Human
Unigene: 22183 Mouse
Unigene: 282284 Mouse
Unigene: 402679 Mouse
Unigene: 17292 Rat
Unigene: 19855 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.