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货号： bs-9472R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9472R-HRP
- 英文名称
- Anti-Myocardin/HRP
- 中文名称
- 辣根过氧化物酶标记的促血管平滑肌细胞分化因子抗体
- 别 名
- MYCD; MYCD_HUMAN; Myocardin; Myocd.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 免疫学 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 103kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Myocardin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage.
Function:
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).
Subunit:
Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle.
Post-translational modifications:
Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity.
Similarity:
Contains 3 RPEL repeats.
Contains 1 SAP domain.
Database links:Entrez Gene: 93649 Human
Entrez Gene: 214384 Mouse
Entrez Gene: 396571 Pig
Entrez Gene: 246297 Rat
Omim: 606127 Human
SwissProt: Q8IZQ8 Human
SwissProt: Q8VIM5 Mouse
SwissProt: Q8R5I7 Rat
Unigene: 567641 Human
Unigene: 32257 Mouse
Unigene: 163103 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.