概述| 货号 | RDC0856 |
| 别名 | EC 2.7.10; EC 2.7.10.1; insulin receptor-related protein; insulin receptor-related receptor; IRR; IRRIR-related receptor |
全称 | Insulin Receptor-related Receptor | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3645 (Human); 23920 (Mouse) |
| 背景 | Insulin Receptor (INSR, CD220) is a type I transmembrane glycoprotein in the Insulin/IGF Receptor family of receptor tyrosine kinases. The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor. All receptor combinations bind Insulin, IGF-I, or IGF-II, but with differing affinities. Insulin R signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. Mutations in INSR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Cytokines in Lipid/Cholesterol Metabolism
- Diabetes
- Glucose Homeostasis
- Growth Hormone/IGF-I Axis
- Nutrition and Appetite
- Protein/Peptide Hormones and Regulators
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
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