Human Jagged 1 (NP 000205) VersaClone cDNA (10 UG)
货号：
RDC0722 基本售价：
11332.3 元 规格：
10 ug
产品信息
概述| 货号 | RDC0722 |
| 别名 | AGS; AHDMGC104644; Alagille syndrome; AWS; CD339 antigen; CD339; HJ1; JAG1; jagged 1; Jagged1; JAGL1; protein jagged-1 |
| 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 182 (Human); 29146 (Rat) |
| 背景 | Mammalian Jagged proteins are homologs of the Drosophila Notch ligand, Serrate, and together with Delta-like proteins, constitute ligands for the mammalian Notch proteins. Jagged 1 and 2 are 180 kDa and 150 kDa type I transmembrane glycoproteins, respectively, that possess extracellular DSL (delta, serrate, lag-2 consensus sequence) domains necessary for binding to Notch receptors, along with 15-16 calcium-binding EGF-like repeats which modulate the binding affinity. Jagged-Notch signaling specifies cell fate, regulates pattern formation, defines boundaries between different cell types, and modulates cell proliferation and differentiation, especially during hematopoiesis, myogenesis, neurogenesis and development of the vasculature. Since both the ligands and receptors are transmembrane proteins, direct cell-cell interactions are thought to be required for functional Notch signaling. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Cancer Biomarkers
- Delta-like Proteins
- EMT Induction
- Human CD Marker Products
- ICC / IHC Images: Jagged 1
- Notch Family
- Notch Pathway
- Notch Receptors
- Taking Advantage of Notch in Stem Cell Expansion
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