Human Frizzled-8 (NP 114072) VersaClone cDNA (10 UG)
货号：
RDC0816 基本售价：
7078.9 元 规格：
10 ug
产品信息
概述| 货号 | RDC0816 |
| 别名 | frizzled (Drosophila) homolog 8; frizzled 8; frizzled family receptor 8; frizzled homolog 8 (Drosophila); frizzled-8; FZ-8; FZD8; hFZ8 |
| 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 8325 (Human); 14370 (Mouse) |
| 背景 | This group of G protein-coupled receptors consists of 10 structurally-related, seven transmembrane proteins with a divergent N-terminal signal peptide and a variable-length C-terminal tail. The Frizzled family proteins contain a highly conserved cysteine-rich domain and a variable length linker region. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Planar Cell Polarity and Wnt/Ca2+Pathways). Wnt/Frizzled signaling is involved in a variety of developmental processes including cell fate determination, cell polarity, tissue patterning, and control of cell proliferation. Activation of a given Wnt/Frizzled signaling cascade is dependent on the Wnt ligand and the cell context. Frizzled proteins also form co-receptor complexes with LRP, ROR, and Ryk molecules. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Frizzled Receptors
- Mini-review: Wnt Receptors & Pathways
- Ryk: A Wnt Co-receptor at the Intersection of Frizzled & Dishevelled
- Technical Notes: Wnt Inhibitor Activity
- Wnt Family
- Wnt Receptors
- Wnt Signaling and sFRPs
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